Substance P Enhances Excitatory Synaptic Transmission on Spinally 1 Projecting Neurons in the Rostral Ventromedial Medulla After Inflammatory 2 Injury
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چکیده
Substance P Enhances Excitatory Synaptic Transmission on Spinally 1 Projecting Neurons in the Rostral Ventromedial Medulla After Inflammatory 2 Injury 3 Liang Zhang and Donna L. Hammond 4 Departments of Anesthesia and Pharmacology 5 The University of Iowa 6 Iowa City, IA 52242 U.S.A. 7 Abstract: 249 words Introduction: 697 words Discussion: 2142 words 8 Tables: 0 Figures: 8 9 Running Title: Inflammation enhances excitatory inputs to RVM neurons 10 Correspondence to: 11 Liang Zhang, M.D. M.S. 12 Department of Anesthesia 13 University of Iowa 14 3000 Medical Laboratory Building 15 Iowa City, IA 52242 16 +1-319-335-8117 (voice) 17 +1-319-384-4567 (fax) 18 [email protected] 19 Articles in PresS. J Neurophysiol (June 3, 2009). doi:10.1152/jn.91337.2008
منابع مشابه
Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
It has been proposed, but not directly tested, that persistent inflammatory nociception enhances excitatory glutamatergic inputs to neurons in the rostral ventromedial medulla (RVM), altering the activity and function of these neurons. This study used whole cell patch-clamp methods to record evoked excitatory postsynaptic currents (eEPSCs) in spinally projecting RVM neurons from rats injected w...
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